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《医学前沿(英文)》 2022年 第16卷 第5期 页码 760-765 doi: 10.1007/s11684-021-0899-5
关键词: lung transplantation donation after brain death waitlist
The influence of brain death on donor liver and the potential mechanisms of protective intervention
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 8-14 doi: 10.1007/s11684-011-0109-y
Brain-dead donors have become one of the main sources of organs for transplantation in Western countries. The quality of donor organs is closely related to the outcome of the transplantation. Experimental studies have confirmed the inferior graft survival of livers from brain-dead donors compared with those from living donors. Studies conducted in the past 10 years have shown that brain death is associated with effects on the decreased donor organ quality. However, whether the decrease in the viability of donor organs is caused by brain death or by the events before and after brain death remains uncertain. The purpose of this review is to introduce the advances and controversies regarding the influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective interventions for donor livers.
关键词: brain death donor liver
Experimental study on the establishment and maintenance of brain death model with pigs
ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi
《医学前沿(英文)》 2007年 第1卷 第2期 页码 161-166 doi: 10.1007/s11684-007-0030-6
Protein aggregation in association with delayed neuronal death in rat model of brain ischemia
GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei
《医学前沿(英文)》 2008年 第2卷 第1期 页码 70-74 doi: 10.1007/s11684-008-0013-2
Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov
《医学前沿(英文)》 2019年 第13卷 第4期 页码 420-426 doi: 10.1007/s11684-019-0688-6
关键词: stroke blood–brain barrier autoimmunity innate immunity inflammation cell death
XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai
《医学前沿(英文)》 2008年 第2卷 第3期 页码 264-268 doi: 10.1007/s11684-008-0050-x
关键词: resistance infrared infrared videomicroscopy depressive after-hyperpolarization potential
Orlistat induces ferroptosis-like cell death of lung cancer cells
《医学前沿(英文)》 2021年 第15卷 第6期 页码 922-932 doi: 10.1007/s11684-020-0804-7
Cooling strategies and transport theories for brain hypothermia resuscitation
LIU Jing
《能源前沿(英文)》 2007年 第1卷 第1期 页码 32-57 doi: 10.1007/s11708-007-0004-z
关键词: mathematical interruption hypothermia metabolic generation
Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports
CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao
《医学前沿(英文)》 2007年 第1卷 第3期 页码 338-342 doi: 10.1007/s11684-007-0065-8
关键词: sarcoplasmic coagulation acquired ventricular myocardium sino-atrial autopsied
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 411-415 doi: 10.1007/s11684-012-0226-2
Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patients and tramadol possesses potential antidepressant effects. Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-related kinase B (TrkB) is a high affinity catalytic receptor for BDNF. We hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects with significant changes in hippocampal BDNF and TrkB levels in rats. Immobility time of rats receiving different treatment in the forced swimming test (FST) was observed. Levels of BDNF and TrkB in hippocampus were measured by enzyme linked immunosorbent assay. Results showed that tramadol (5 mg/kg) administrated alone neither elicited antidepressant effects nor altered BDNF or TrkB level. However, pretreatment with tramadol (5 mg/kg) enhanced the ketamine (10 mg/kg) -elicited antidepressant effects and upregulated the BDNF and TrkB levels in hippocampus. In conclusion, tramadol pretreatment reinforces the ketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat hippocampus.
关键词: tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B
Various brain-eating amoebae: the protozoa, the pathogenesis, and the disease
《医学前沿(英文)》 2021年 第15卷 第6期 页码 842-866 doi: 10.1007/s11684-021-0865-2
关键词: free-living amoebae central nervous system infection primary amoebic meningoencephalitis granulomatous amoebic encephalitis
Guoxia MA, Jinnan WANG, Fang YU, Xiaomin GUO, Yanshen ZHANG, Chao LI
《环境科学与工程前沿(英文)》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0849-7
关键词: Air pollution Public health Premature deaths Health assessment
《化学科学与工程前沿(英文)》 2022年 第16卷 第4期 页码 536-545 doi: 10.1007/s11705-021-2067-5
关键词: BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel
富含sn-2 DHA脂质对大脑的益处及其酶法合成综述 Review
金俊, 金青哲, 王兴国, Casimir C. Akoh
《工程(英文)》 2020年 第6卷 第4期 页码 424-431 doi: 10.1016/j.eng.2020.02.009
大脑中二十二碳六烯酸(DHA, ω-3脂肪酸)的含量与中枢神经系统的正常发育和功能维持高度相关。甘油酯sn-2位上的DHA可以被肠黏膜更好地吸收,从而实现机体对DHA的高效利用。然而,如今人们在饮食中摄入较多的饱和脂肪或富含ω-6脂肪酸的油脂,而摄入较少的DHA,从而导致了部分个体在行为和神经生理学方面的缺陷。为了全面了解DHA对大脑的有益功能,本文系统介绍了天然油脂甘油骨架上DHA的位置分布(sn-2和sn-1,3位)特征,并讨论了DHA补充和通过肠-脑轴传递信息的潜在功能机制。肠-脑轴包含的多条双向信息通道为DHA、肠道菌群和大脑健康的相互作用提供了新的研究思路。为了在日常饮食中摄入更多的sn-2 DHA,我们建议通过更为高效和经济的酯交换制造技术生产富含sn-2 DHA脂质,其中需要解决的关键技术包括强化酶的特异性和优化纯化工艺。这类饮食可满足对sn-2 ω-3脂质有强烈需求的人群,特别是婴儿、儿童、孕妇和哺乳期妇女。
关键词: DHA 和 sn-2 DHA 单甘酯 大脑 肠-脑轴 结构脂质
从脑科学到人工智能 Review
范静涛, 方璐, 吴嘉敏, 郭雨晨, 戴琼海
《工程(英文)》 2020年 第6卷 第3期 页码 248-252 doi: 10.1016/j.eng.2019.11.012
回顾人工智能(artificial intelligence, AI)的发展历史,我们可以清晰地看到脑科学给AI领域带来的巨大突破,如深度学习。目前,尽管AI及其应用的发展趋势已经超越了人类的预期,但AI与人类智能之间仍然存在着难以逾越的鸿沟。从脑科学到AI、从了解大脑到模拟大脑,在脑科学与AI研究之间建立起一座桥梁已经成为一种迫切需求。为此,我们首先需要通过研究新型脑成像技术来探索脑科学的秘密,建立大脑的动态连接图谱以及将神经科学实验与理论、模型和统计学相结合等。在此基础上,我们将进一步研究新一代AI理论和方法,从而建立起从机器感知和机器学习到机器思维和机器决策的颠覆性模型和工作模式。与此同时,本文还将讨论在脑科学启发新一代AI过程中的一些机遇与挑战。
关键词: 人工智能,脑科学
标题 作者 时间 类型 操作
Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death
期刊论文
The influence of brain death on donor liver and the potential mechanisms of protective intervention
null
期刊论文
Experimental study on the establishment and maintenance of brain death model with pigs
ZHANG Shuijun, SHI Jihua, ZHAI Wenlong, SONG Yan, CHEN Shi
期刊论文
Protein aggregation in association with delayed neuronal death in rat model of brain ischemia
GE Pengfei, FU Shuanglin, LI Wenchen, WANG Chonghao, ZHOU Chuibing, LUO Yinan, LUO Tianfei
期刊论文
Autoimmunity in acute ischemic stroke and the role of blood—brain barrier: the dark side or the light
Nikolay V. Tsygan, Alexandr P. Trashkov, Igor V. Litvinenko, Viktoriya A. Yakovleva, Alexandr V. Ryabtsev, Andrey G. Vasiliev, Leonid P. Churilov
期刊论文
Spontaneous firing properties of rat medial vestibular nucleus neurons in brain slices by infrared visual
XIA Jiao, KONG Weijia, ZHU Yun, ZHOU Yan, ZHANG Yu, GUO Changkai
期刊论文
Sudden death due to arrhythmogenic right ventricular cardiomyopathy: Two case reports
CHEN Xinshan, ZHANG Yigu, RAO Guangxun, HUANG Guangzhao
期刊论文
Tramadol reinforces antidepressant effects of ketamine with increased levels of brain-derived neurotrophic
null
期刊论文
Assessing the premature death due to ambient particulate matter in China’s urban areas from 2004 to 2013
Guoxia MA, Jinnan WANG, Fang YU, Xiaomin GUO, Yanshen ZHANG, Chao LI
期刊论文
acting carmustine loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after
期刊论文